Contribution of genetic background in HIV elite controllers
نویسندگان
چکیده
منابع مشابه
Effect of antiretroviral therapy on HIV reservoirs in elite controllers.
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in the absence of antiretroviral therapy (ART). However, precise frequencies of CD4(+) T cells carrying replication-competent HIV and/or the dynamics of the infectious viral reservoirs in response to initiation and discontinuation of ART in elite controllers are unknown. We show that the size o...
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Elite controllers maintain HIV-1 viral loads below the limit of detection. The mechanisms responsible for this phenomenon are poorly understood. As microRNAs (miRNAs) are regulators of gene expression and some of them modulate HIV infection, we have studied the miRNA profile in plasma from HIV elite controllers and chronically infected individuals and compared against healthy donors. Several mi...
متن کاملBlunted Response to Combination Antiretroviral Therapy in HIV Elite Controllers: An International HIV Controller Collaboration
OBJECTIVE HIV "elite controllers" (ECs) spontaneously control viral load, but some eventually require combination antiretroviral treatment (cART), due to a loss of viral control or a decline in CD4 T-cell counts. Here we studied the CD4 T-cell count dynamics after cART initiation among 34 ECs followed in U.S. and European cohorts, by comparison with chronically viremic patients (VIRs). METHOD...
متن کاملContribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons.
BACKGROUND Persons infected with human immunodeficiency virus (HIV) have increased rates of coronary artery disease (CAD). The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CAD has not been fully evaluated in the setting of HIV infection. METHODS In the general population, 23 common single-nucleotide polymorphisms...
متن کاملHospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV Infection.
BACKGROUND Elite controllers spontaneously suppress human immunodeficiency virus (HIV) viremia but also demonstrate chronic inflammation that may increase risk of comorbid conditions. We compared hospitalization rates and causes among elite controllers to those of immunologically intact persons with medically controlled HIV. METHODS For adults in care at 11 sites from 2005 to 2011, person-yea...
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ژورنال
عنوان ژورنال: Journal of Contemporary Clinical Practice
سال: 2019
ISSN: 2457-7200
DOI: 10.18683/jccp.2019.1048